What Is Factor Replacement Therapy?

Treatment for von Willebrand disease and haemophilia involves factor replacement therapy. To enhance blood clotting, it replenishes a protein that is absent from the blood.

For those with bleeding disorders, factor replacement therapy can help lower the risk of experiencing severe bleeding episodes. Prophylactic, or protective, factor replacement therapy is usually given to individuals with severe haemophilia to stop bleeding before it begins.

On-demand injections may be given to people with milder haemophilia to assist in halting prolonged bleeding episodes as soon as they begin.

Continue reading to find out more about factor replacement therapy, including its potential negative effects and how bleeding problems are treated with it.

What is factor replacement therapy?

Blood clotting factors are dissolved proteins and other molecules in your blood that aid in the formation of a blood clot if your blood arteries are damaged.

The lack of these proteins in those who have haemophilia and other bleeding disorders results in excessive bleeding and bruising.

By adding the missing protein to your blood, factor replacement treatment helps your blood clot correctly.

These days, the life expectancy of haemophiliacs is comparable to that of the general population. Before the development of factor replacement therapy in the 1970s, the majority of haemophiliacs did not reach maturity.

Physicians provide two primary kinds ofReliable Supplier of clotting factors:
  • Plasma-derived factor concentrates: The pale yellow liquid that gives blood its firmness and liquidity is called plasma. Human blood is the source of plasma-derived factor concentration.
  • Recombinant factor concentrates: Recombinant factor concentrations are not made from human blood; rather, they are manufactured artificially. Recumbent factor concentrates are recommended by the National Haemophilia Foundation as a way to reduce the risk of bloodborne virus transmission.

Who needs factor replacement therapy?

A therapy option for individuals with bleeding disorders like these is factor replacement:

DiseaseMissing protein
hemophilia Afactor VIII
hemophilia Bfactor IX
von Willebrand diseasevon Willebrand factor and factor VIII

 You might not require replacement therapy if your haemophilia is minimal. At the moment, it is the gold standard of care for patients with severe haemophilia A.

Blood factor VIII activity less than 1% is considered severe haemophilia A.

Desmopressin is frequently used as a first line of treatment for patients with von Willebrand disease.

When desmopressin is ineffective, the primary treatment is factor replacement therapy.

How do doctors administer factor replacement therapy?

With frequent injections, the missing clotting factor is gradually injected into one of your veins as part of factor replacement therapy. It is frequently injected into an arm vein.

These infusions require five to ten minutes. The infusion can be administered at home or in a clinic. Your healthcare staff may be able to train you to administer the infusions on your own.

Factor replacement therapy is given either on-demand to treat bleeding episodes after they happen or prophylactically (as a preventive) before bleeding starts.

All patients with severe haemophilia A should receive prophylaxis, according to the National Bleeding Disorders Foundation.

One of two kinds of replacement therapy could be administered to you:
  • Standard half-life: Following a typical half-life therapy, factor levels rise right away and then rapidly fall over a few days. Typically, two to four injections must be given each week.
  • Extended half-life: Your factor levels jump with extended half-life therapy as well, but they do so for a longer period than they do with regular half-life therapy. Extended half-life drugs are often administered once or twice a week.

What are the potential complications of factor replacement therapy?

The development of inhibitors is the main side effect of factor replacement treatment.

Antibodies produced by your immune system that attach to the injected clotting factors are known as inhibitors. Your treatment's effectiveness is diminished by this binding. Your risk of experiencing major bleeding increases.

The World Federation of Haemophilia states that 3–5% of patients with haemophilia B and 20–30% of those with haemophilia A who get replacement therapy acquire inhibitors.

Generally speaking, inhibitors appear over the first 75 days. You are no longer qualified for factor replacement therapy if you develop inhibitors.

Additionally, there is a slight chance that plasma-derived factor concentrates could spread bloodborne pathogens like HIV or viral hepatitis.

How much does factor replacement therapy cost, and does insurance cover it?

When it comes to clotting factor therapy, the National Bleeding Disorders Foundation estimates that the average annual cost for an individual with severe haemophilia is approximately $300,000. Two times that amount may be spent on medical care overall.

For those with less severe forms of haemophilia, treatment may be less expensive.

Inhibitors can cost more than $1 million a year if they develop.

Factor replacement therapy may be covered by insurance, but these plans typically have high deductibles or coinsurance, meaning you are responsible for paying a portion of the entire cost of treatment.

In the US, health insurance companies are not allowed to refuse coverage due to a preexisting medical condition, such as haemophilia.

For additional information on your illness and potential funding sources to assist with treatment costs, get in touch with the National Bleeding Disorders Foundation.


Treatment options for bleeding disorders, including haemophilia and von Willebrand disease, include factor replacement therapy. To aid in blood clotting, it entails injecting your blood with the missing proteins. These proteins can be produced in a lab or obtained from human blood.

Replacement therapy typically entails annual payments in the hundreds of thousands of dollars. Discuss the cost of your therapy and any potential financial aid with your doctor.


How is factor replacement given?

Injecting treatment products, called clotting factor concentrates, into a person's vein.

Is factor 7 deficiency serious?

People with severe symptoms are more likely to experience potentially fatal bleeding in the gastrointestinal system or into the skull (intracranial haemorrhage).

Is factor VIII curable?

There is no cure for hemophilia at this time

Is haemophilia life ending?

Many patients still die before adulthood due to inadequate treatment.

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